Prematurity, together with its complication, remains the most frequent preventable cause of neonatal loss. In an attempt to prevent the sequalae of premature delivery attention has logically centered on effort to find safe and effective tocolytic
drugs.
The drugs most commonly used in this country for the suppression of preterm labor are ritodrine hydrochloride and magesium sulfate and its efficacies were assessed by several means.
This study was undertaken to assess the clinical efficacies of ritodrine hydrochloride and magesium sulfate on 78 patients admitted with preterm labor from Jan. 1, 1990 to Dec. 31, 1992.
@ES The results were as follows:
@EN 1. The incidence of preterm labor was 8.6~9.5% of total number of delivery.
2. The risk factors of the preterm labor were premature rupture of membrane, incom petent cervix, previous preterm delivery, placenta previa, chorioamnionitis, hydroamnios, twin pregnancy, pyelonephritis, and uterine myoma in order, but 37% of
preterm
labor had no apparent risk factors.
3. The days gain in uterus was no statistically difference between the ritodrine group and the magrose group but markedly longer in the two groups than the control group (P<0.01). And the delivery time was also no statistically difference
between
the
ritodrine group and the magrose group but significantly increased in the two groups than the control group(p<0.05).
4. The rate of full success and incomplete success was similar as 15.9% and 27.3%(total success rate 43.2%) in the ritodrine group, 11.7% and 26.6%(total success rate 43.2%) in the ritodrine group, 11.7% and 26.6%(total success rate 38.3%) in
the
magrose group but only 18.0% incomplete success rate was showed in the control group.
5. The side effects were much more in the ritodrine group than the magrose group but patients requiring second-line therapy were much more in the magrose group than the ritodrine group.
6. Mean body weight and Apgar score of neonates were similar in the three groups but the respiratory distreas syndrome was decreased in the ritodrine group than the magrose and control groups without statistical significance.
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